UPDATE: 8 p.m.

A stabbing rampage on a Saskatchewan First Nation and in a nearby village left 10 people dead and 15 others injured, provincial RCMP said Sunday as officers continued to search for two suspects.

“We believe some of the victims have been targeted by the suspects and others have been attacked randomly,” Rhonda Blackmore, the assistant commissioner in charge of Saskatchewan RCMP, told reporters in Regina.

“It is horrific what has occurred in our province today.”

Blackmore said the 15 injured were taken to hospital but there may be more who sought medical help on their own.

The attacks took place at 13 different locations on the James Smith Cree Nation and nearby Weldon, northeast of Saskatoon, she said.

She declined to comment on how officers know some of the victims were targeted, saying that remains part of the investigation.

Blackmore said police began receiving reports before 6 a.m. of stabbings on the First Nation. More reports of attacks quickly followed and by midday police issued a warning that a vehicle reportedly carrying the two suspects had been spotted in Regina.

Officers began scouring the city and security was boosted at Mosaic Stadium, as thousands of fans descended on the city for a sold out annual Labour Day game between the Canadian Football League's Saskatchewan Roughriders and Winnipeg Blue Bombers.

A dangerous persons alert for Damien Sanderson, 31, and Myles Sanderson, 30, was also in effect from Alberta to Manitoba.

"If Damien and Myles are listening, or receive this information, I would ask that they turn themselves into police immediately," said Blackmore.

“They’re considered armed and dangerous … at this point we don’t know if they have changed vehicles since this morning. Their location and direction of travel is unknown."

Damien Sanderson is described as five feet seven inches tall and 155 pounds, and Myles Sanderson as six-foot-one and 200 pounds. Both have black hair and brown eyes and may be driving a black Nissan Rogue with licence plate 119 MPI.

Weldon residents have identified one of the victims as Wes Petterson.

Ruby Works said the 77-year-old widower was like an uncle to her.

"I collapsed and hit the ground. I've known him since I was just a little girl," she said, describing the moment she heard the news.

She said he loved his cats, was proud of his homemade Saskatoon berry jam and frequently helped out his neighbours.

"He didn't do anything. He didn't deserve this. He was a good, kind hearted man," said Works.

She said the event has shaken a community where the sounds of sirens are rarely heard.

"No one in this town is ever going to sleep again. They're going to be terrified to open their door," she said.

Weldon resident Robert Rush also described the victim as a gentle, widowed man in his 70s.

"He wouldn't hurt a fly," he said.

Rush said Petterson's adult grandson was in the basement at the time and phoned police.

"He stayed down there until they were gone."

Rush said people in Weldon believe the suspects left the village. Later Sunday, he drove to Prince Albert to buy a cake for his wife's birthday and left his granddaughter at home.

"I gave her two guns and a bat," Rush said.

At the Weldon Christian Tabernacle Church the congregation began their regular Sunday service by saying a special prayer to the victims and their families.

At the James Smith Cree Nation, a convenience store that also serves as a gas station became a gathering place for community members, who greeted each other with tears and hugs.

A sign on the door said: “Due to safety concerns with our community we will remain closed until further notice."

The elected leaders of the three communities that make up the James Smith Cree Nation, including the Chakastaypasin Band and the Peter Chapman Band, declared a local state of emergency on Sunday.

Chakastaypasin Chief Calvin Sanderson said he'd left his phone off on Sunday morning and only learned of the tragic events when community members came to his door to check on him.

Everyone's been affected, he said.

"They were our relatives, friends. Mostly we're all related here, so it's pretty hard," Sanderson said.

"It's pretty horrific."

The emergency declaration, which was released by the Federation of Sovereign Indigenous Nations, said two emergency operations centres have been set up.

The Saskatchewan Health Authority said multiple patients were being treated at several sites.

"A call for additional staff was issued to respond to the influx of casualties,'' authority spokeswoman Anne Linemann said in an email.

Mark Oddan, a spokesman with STARS Air Ambulance, said two helicopters were dispatched from Saskatoon and another from Regina.

He said two carried patients to Royal University Hospital in Saskatoon, while the third carried a patient to Royal University from a hospital in Melfort, a short distance southeast of Weldon.

Saskatchewan Premier Scott Moe responded to the tragedy on Twitter.

“I want to offer my deepest condolences on behalf of the government and people of Saskatchewan to all of the family and friends of the victims of today’s horrific attacks."

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UPDATE: 6:35 p.m.

On Sept. 4, two suspects allegedly went on a rampage across part of Saskatchewan. Police say 10 people died and 15 others were injured over the 13 locations where the attacks took place. Here's a timeline of the police response. All times local:

5:40 a.m. - RCMP receives multiple calls from James Smith Cree Nation about stabbings at different locations.

7:12 a.m. - Saskatchewan RCMP issues dangerous persons alert, says police trying to locate two suspects. Area residents of James Smith Cree Nation and surrounding communities of Candle Lake, Prince Albert, Melfort, Humboldt and Rosthern told to seek immediate shelter, use caution.

7:57 a.m. - RCMP releases names and photos of suspects: Damien Sanderson and Myles Sanderson. Damien Sanderson is described as five-feet-seven inches, 155 pounds with black hair, brown eyes. Myles Sanderson was described as six-feet-one inch, 200 pounds with black hair and brown eyes.

8:20 a.m. - RCMP extends dangerous persons alert to province of Saskatchewan, saying the suspects are believed to be travelling in a vehicle.

9:45 a.m. - RCMP issues fourth dangerous persons alert saying there have been multiple victims in multiple locations, at least one at James Smith Cree Nation and another victim at Weldon. Some of the attacks appear to be random.

11:25 a.m. - RCMP sends request to Mounties in Manitoba and Alberta to extend dangerous persons alert to their provinces.

12:07p.m. - RCMP issues fifth update saying witnesses report seeing suspect vehicle in Regina on Arcola Ave. Residents asked to shelter in place. The vehicle is described as a black Nissan Rogue with Saskatchewan license plate 119 MPI.

3:45 p.m. - RCMP announces 10 people have been killed and 15 others injured in the attacks, which they say took place across 13 locations.

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UPDATE 5:20 p.m.

Details about some of the victims are starting to emerge.

The attacks took place at 13 different locations on the James Smith Cree Nation and nearby Weldon, northeast of Saskatoon, she said.

Police began receiving reports before 6 a.m. of stabbings on the First Nation. More reports of attacks quickly followed and by midday police issued a warning that a vehicle reportedly carrying the two suspects had been spotted in Regina.

Officers began scouring the city and security was boosted at Mosaic Stadium, as thousands of fans descended on the city for a sold out annual Labour Day game between the Canadian Football League's Saskatchewan Roughriders and Winnipeg Blue Bombers.

A dangerous persons alert for Damien Sanderson, 31, and Myles Sanderson, 30, was also in effect from Alberta to Manitoba.

"If Damien and Myles are listening, or receive this information, I would ask that they turn themselves into police immediately," said RCMP Assistant Commissioner Rhonda Blackmore.

“They’re considered armed and dangerous ... at this point we don’t know if they have changed vehicles since this morning. Their location and direction of travel is unknown."

Damien Sanderson is described as five feet seven inches tall and 155 pounds, and Myles Sanderson as six-foot-one and 200 pounds. Both have black hair and brown eyes and may be driving a black Nissan Rogue with licence plate 119 MPI.

Weldon resident Diane Shier said she was in her garden Sunday morning when she noticed emergency crews a couple of blocks away.

Shier said her neighbour, a man who lived with his grandson, was killed. She did not want to identify the victim out of respect for his family.

“I am very upset because I lost a good neighbour."

Weldon resident Robert Rush also described the victim as a gentle, widowed man in his 70s. "He wouldn't hurt a fly."

He said the victim's adult grandson was in the basement at the time and phoned police.

"He stayed down there until they were gone."

Rush said people in Weldon believe the suspects left the village. Later Sunday, he drove to Prince Albert to buy a cake for his wife's birthday and left his granddaughter at home.

"I gave her two guns and a bat," Rush said.

The James Smith Cree Nation said it had declared a state of emergency and set up two operations centres to support people in the area.

The Saskatchewan Health Authority said multiple patients were being treated at several sites.

"A call for additional staff was issued to respond to the influx of casualties,'' authority spokeswoman Anne Linemann said in an email.

Mark Oddan, a spokesman with STARS Air Ambulance, said two helicopters were dispatched from Saskatoon and another from Regina.

He said two carried patients to Royal University Hospital in Saskatoon, while the third carried a patient to Royal University from a hospital in Melfort, a short distance southeast of Weldon.

Saskatchewan Premier Scott Moe responded to the tragedy on Twitter.

“I want to offer my deepest condolences on behalf of the government and people of Saskatchewan to all of the family and friends of the victims of today’s horrific attacks,” said Moe.

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UPDATE 3:10 p.m.

RCMP say 10 people have died and 15 have been sent to hospitals after stabbings in multiple locations in Saskatchewan.

They say they are looking for two suspects — Damien and Myles Sanderson — who are considered armed and dangerous.

RCMP Assistant Commissioner Rhonda Blackmore says the dead and injured were found in 13 locations on the James Smith Cree Nation and in the village of Weldon, northeast of Saskatoon.

She says the injured have been taken to various hospitals, and there may be other victims who went to hospitals on their own.

She says some people were targeted and others were attacked at random.

"It is horrific what has happened in our province today," she said.

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UPDATE: 1:15 p.m.

RCMP in Saskatchewan have expanded an alert to neighbouring provinces for two suspects on the loose after multiple stabbings in numerous locations.

The alert first issued by the Melfort RCMP around 7 a.m. local time has now been extended to cover Manitoba and Alberta, as the two suspects remain at large.

RCMP have said stabbings took place in locations including the James Smith Cree Nation and Weldon, Sask., and early indications suggest victims may have been attacked at random, but they have not said how many were injured.

Police say the suspects they're seeking may have been in Regina late Sunday morning.

Damien Sanderson is described as 5-foot-7 and 155 pounds, and Myles Sanderson is 6-foot-1 and 200 pounds. Both have black hair and brown eyes and may be driving a black Nissan Rogue with licence plate 119 MPI.

The Saskatchewan Health Authority says multiple patients are being treated at multiple sites.

"A call for additional staff was issued to respond to the influx of casualties," authority spokeswoman Anne Linemann said in an email."

Mark Oddan, a spokesman with STARS Air Ambulance, says two helicopters were dispatched from Saskatoon and another from Regina. Two carried patients from the scene to Royal University Hospital in Saskatoon, while the third carried a patient to Royal University from a hospital in Melfort.

Oddan says due to privacy laws, he is not able to disclose information about their ages, genders or conditions.

He says other patients were transported by ground ambulance to hospitals in Prince Albert, Nipawin and Melfort, but he didn't know how many.

Oddan says the second chopper dispatched from Saskatoon carried a transport physician to the scene to assist with operations on the ground, but he did not know the location.

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ORIGINAL: 12:20 p.m.

RCMP in Saskatchewan have expanded an alert to two neighbouring provinces for two suspects on the loose after multiple stabbings in numerous locations.

The alert first issued around 7 a.m. has now been extended to cover Manitoba and Alberta.

RCMP have said stabbings took place in locations including the James Smith Cree Nation and Weldon, Sask., but have not said how many victims are involved.

The Saskatchewan Health Authority says multiple patients are being treated at multiple sites, but declined to offer further details.