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Photo: The Canadian Press. All rights reserved.

Motorists travel slowly on a snow-covered Interstate 24 during a winter storm Wednesday, December 26, 2012, in Paducah, Ky. The storm dumped several inches of snow making travel hazardous. (AP Photo/Stephen Lance Dennee)

The death toll has risen to six from winter storms in the U.S. midsection that are pushing toward the Northeast.

Two passengers in a car on a sleet-slickened Arkansas highway died Wednesday when the vehicle crossed the centre line and struck an SUV.

In Oklahoma, the Highway Patrol said a 76-year-old woman died Tuesday when a truck crossed into oncoming traffic and hit the car she was in. The Highway Patrol earlier reported that a 28-year-old woman was killed in another crash.

The storm's winds were also blamed Tuesday for toppling a tree onto a truck in Texas, killing the driver, and a tree onto a house in Louisiana, killing a man.

More than 325 flights around the U.S. were cancelled as of Wednesday morning, according to the flight tracker FlightAware.com. Most were at airports in the path of the storm.