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Photo: The Canadian Press. All rights reserved.

FILE - This Nov. 28, 2012 file photo shows UN Ambassador Susan Rice leaving a meeting on Capitol Hill in Washington. Rice has withdrawn from consideration for secretary of state. (AP Photo/ Evan Vucci, File)

Susan Rice, the embattled U.N. ambassador, abruptly withdrew from consideration to be the next secretary of state on Thursday after a bitter, weekslong standoff with Republican senators who declared they would fight to defeat her nomination.

The reluctant announcement makes Massachusetts Sen. John Kerry the likely choice to be the nation's next top diplomat when Hillary Rodham Clinton departs soon. Rice withdrew when it became clear her political troubles were not going away, and support inside the White House for her potential nomination had been waning in recent days, administration officials said.

In another major part of the upcoming Cabinet shake-up for President Barack Obama's second term, former Republican Sen. Chuck Hagel of Nebraska now is seen as the front-runner to be defence secretary, with official word expected as soon as next week.

For the newly re-elected president, Rice's withdrawal was a sharp political setback and a sign of the difficulties Obama faces in a time of divided and divisive government. Already, he had been privately weighing whether picking Rice would cost him political capital he would need on later votes.

When Rice ended the embarrassment by stepping aside, Obama used the occasion to criticize Republicans who were adamantly opposed to her possible nomination.

"While I deeply regret the unfair and misleading attacks on Susan Rice in recent weeks, her decision demonstrates the strength of her character," he said.

"I am saddened we have reached this point," Rice said.

Obama made clear she would remain in his inner circle, saying he was grateful she would stay as "our ambassador at the United Nations and a key member of my Cabinet and national security team." Rice, too, said in her letter she would be staying.