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The Mondelez cookie and cracker factory in Montreal will close by the end of 2017, resulting in the disappearance of 454 jobs.
The job losses will take place on a gradual basis.
Company spokeswoman Stephanie Cass says the decision followed a company review of its supply chain.
Cass did not provide many details, calling it a "difficult day" for employees.
She said the company will maintain its activities in its five other Canadian factories.
It's best-known product is the Canadian licensed production of Oreo cookies for Christie.