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Photo: The Canadian Press. All rights reserved.

Authorities investigate a passenger bus crash on the Pennsylvania Turnpike on Saturday, March 16, near Carlisle, Pa. (AP Photo/The Patriot-News, Joe Hermitt)

A tour bus carrying a college's women's lacrosse team to a game went off the Pennsylvania Turnpike on Saturday and crashed into a tree, killing a pregnant coach and the driver and sending others to hospitals, authorities said.

Lacrosse players from Seton Hill University and three coaches were among the 23 people aboard when the bus crashed at about 9 a.m., turnpike spokeswoman Renee Colborn said. It's not clear what caused the crash, but state police were investigating, said Megan Silverstram of the Cumberland County public safety department.

Kristina Quigley of Greensburg, 30, was flown to a hospital and died there from injuries from the crash, Cumberland County authorities said Saturday that. They say Quigley was about six months pregnant and her unborn child did not survive. The driver, 61-year-old Anthony Guaetta of Johnstown, died at the scene of the crash.

Two other victims were flown by helicopter to Penn State Hershey Medical Center, hospital spokeswoman Danielle Ran said. She did not give their conditions. Officials said all other passengers were taken to hospitals as a precaution.

The bus came to a stop upright on the side of the road with part of its left side shorn off, photos from the scene showed, though it's unclear whether that was from the impact or rescue operation.