UBCO cancer breakthrough

Researchers at UBC Okanagan are shining a new light on cancer treatment.

Researchers discovered a new method of using infrared light to monitor cancer progression during radiation treatment that may lead to better and more personalized therapies.

Cancers are typically treated using a combination of surgery, radiation and chemotherapy. The challenge for physicians is that once a treatment begins, it can last for weeks and usually isn’t adjusted to reflect how the cancer is responding.

“Previous research tells us that patients can be either over- or under-treated with radiation,” says Andrew Jirasek, associate professor of physics at UBCO, one of the study’s lead authors. “The problem is that even cancers of the same type, like breast cancer, can have different behaviours in individual patients.”

“Our goal was to identify a technique that can monitor a cancer’s sensitivity and response to radiation so that the dose can be adjusted to meet an individual patient’s needs,” says Jirasek.

Relatively simple to perform and minimally invasive, Raman spectroscopy provides information about a sample of cancer tissue by shining an infrared light on it. Different components within the cells absorb the infrared light at specific wavelengths, creating a cancer ‘fingerprint’.

“The important difference is that as the cancer is exposed to radiation, levels of particular components in the cells will change over time and so too will the spectral fingerprint,” says Jirasek. “This opens up exciting new opportunities to track the progression in individual patients and personalize their radiation dose.”

While the technique isn’t ready to be applied to cancer patients yet, Jirasek is encouraged by the possibilities.

“This could well open up new avenues for more effective and safer personalized medicine.”

The study was published in the journal Radiation Research.

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